Humanin is a 24-amino-acid mitochondrial-derived peptide (MDP), supplied as a lyophilized research chemical for in vitro laboratory investigation. Third-party lab tested for purity.
Peptides.GG is a chemical supplier and is not a compounding pharmacy under 503A or 503B. Statements have not been evaluated by the US FDA. Products are not intended to diagnose, treat, cure, or prevent any disease. For research use only — not for human consumption.
Humanin
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Humanin is a 24-amino-acid mitochondrial-derived peptide (MDP), supplied as a lyophilized research chemical for in vitro laboratory investigation. Third-party lab tested for purity.
Peptides.GG is a chemical supplier and is not a compounding pharmacy under 503A or 503B. Statements have not been evaluated by the US FDA. Products are not intended to diagnose, treat, cure, or prevent any disease. For research use only — not for human consumption.
Frequently Asked Questions About Humanin
What is Humanin?
Humanin is a 24-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 16S rRNA region (MT-RNR2). It is studied as a research tool in mitochondrial biology and cellular stress signaling, and is supplied for laboratory use only, not for human consumption.
What is a mitochondrial-derived peptide?
A mitochondrial-derived peptide (MDP) is a short peptide encoded within mitochondrial DNA that acts as a signaling molecule. Humanin was among the first MDPs identified; MOTS-c is another. They are studied for roles in cellular signaling and stress responses.
What is the molecular profile of Humanin?
Humanin is a 24-residue peptide with the sequence MAPRGFSCLLLLTSEIDLPVKRRA, molecular formula C₁₁₉H₂₀₄N₃₄O₃₂S₂, and an average molecular weight of approximately 2687.2 Da (monoisotopic 2685.48 Da). CAS 330936-69-1. This product is the native human sequence.
What is Humanin studied for?
In vitro and preclinical research examines Humanin in the context of cytoprotective and anti-apoptotic signaling, cellular stress responses, and metabolic and neuronal research models. It is a research compound only.
How does Humanin relate to MOTS-c?
Both Humanin and MOTS-c are mitochondrial-derived peptides — short peptides encoded within mitochondrial DNA that function in cell signaling. They are distinct compounds with different sequences and are often studied together in mitochondrial-signaling research.
What size is Humanin available in, and how is it stored?
Humanin is supplied as a lyophilized powder in a 10 mg size, kept sealed, cold, and protected from light and moisture until use. Each batch is third-party tested with a Certificate of Analysis.
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Research Overview
Humanin is a 24-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 16S ribosomal RNA region (MT-RNR2). Identified in the early 2000s, it was among the first recognized members of the MDP family — short peptides encoded by mitochondrial DNA that act as signaling molecules. It is studied as a research tool in mitochondrial biology and cellular stress signaling.
Mitochondrial-Derived Peptides and Structure
Humanin has the 24-residue sequence MAPRGFSCLLLLTSEIDLPVKRRA. As a mitochondrial-derived peptide it sits alongside MOTS-c, another mitochondrially encoded peptide in the catalog; the two are frequently examined together in mitochondrial-signaling research. The peptide contains two cysteine residues, which is reflected in its sulfur-containing molecular formula.
Research Applications
In vitro and preclinical research examines Humanin in the context of cytoprotective and anti-apoptotic signaling, cellular stress responses, and metabolic and neuronal research models. Its identification helped establish the broader concept of peptides encoded within the mitochondrial genome that participate in cell signaling.
Variants and Related Peptides
Humanin has engineered and homologous variants — for example the [Gly14] analog (often abbreviated HNG) and the rodent homolog rattin — which are distinct compounds with their own chemistry and should not be conflated with native Humanin. This product is the native human sequence. The most closely related catalog compound is the mitochondrial-derived peptide MOTS-c.
Laboratory Handling
Humanin is supplied as a lyophilized powder, kept sealed, cold, and protected from light and moisture until use. The lyophilized format supports precise gravimetric preparation of research concentrations at the point of use. Each batch is third-party tested with a Certificate of Analysis.
